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[21], The status of THC as an illegal drug in most countries imposes restrictions on research material supply and funding, such as in the United States where the National Institute on Drug Abuse and Drug Enforcement Administration continue to control the sole federally-legal source of cannabis for researchers. Required fields are marked *. The pathway for THCA biosynthesis is similar to that which produces the bitter acid humulone in hops. Delta-9-tetrahydrocannabinol (Δ9-THC), better known to cannabis users simply as THC, is the marijuana plant's primary component for causing psychoactive effects. Wir verwenden Cookies und ähnliche Tools, um Ihr Einkaufserlebnis zu verbessern, um unsere Dienste anzubieten, um zu verstehen, wie die Kunden unsere Dienste nutzen, damit wir Verbesserungen vornehmen können, und um Werbung anzuzeigen, einschließlich interessenbezogener Werbung. In humans and animals, more than 100 metabolites could be identified, but 11-OH-THC and THC-COOH are the dominating metabolites. [8], A total synthesis of the compound was reported in 1965; that procedure called for the intramolecular alkyl lithium attack on a starting carbonyl to form the fused rings, and a tosyl chloride mediated formation of the ether. [31][32] More than 55% of THC is excreted in the feces and ≈20% in the urine. [21], The actions of THC result from its partial agonist activity at the cannabinoid receptor CB1 (Ki = 10 nM[22]), located mainly in the central nervous system, and the CB2 receptor (Ki = 24 nM[22]), mainly expressed in cells of the immune system. [19][20] Nabiximols (as Sativex) is available as a prescription drug in Canada. [23], THC targets receptors in a manner far less selective than endocannabinoid molecules released during retrograde signaling, as the drug has a relatively low cannabinoid receptor affinity. After August 21st, 2020, all forms of THC were deemed illegal above 0.3% under the CSA (Controlled Substances Act), according to the DEA. 0120-15-7352. Over time, or when heated, THCA is decarboxylated, producing THC. Your email address will not be published. Stockingtease, The Hunsyellow Pages, Kmart, Msn, Microsoft, Noaa, Diet, Realtor, Motherless.com, Lobby.com, Hot, Kidscorner.com, Pof, Kelly Jeep, Pichuntercom, Gander Mountain, Accuweather, Bank Of America, Hotels, Zillow Ads. [35][47][48], At its 33rd meeting, in 2003, the World Health Organization Expert Committee on Drug Dependence recommended transferring THC to Schedule IV of the Convention, citing its medical uses and low abuse and addiction potential. [29], THC is metabolized mainly to 11-OH-THC by the body. This metabolite is still psychoactive and is further oxidized to 11-nor-9-carboxy-THC (THC-COOH). Stockingtease, The Hunsyellow Pages, Kmart, Msn, Microsoft, Noaa …. Create a free website or blog at WordPress.com. [23][24] The psychoactive effects of THC are primarily mediated by the activation of cannabinoid receptors, which result in a decrease in the concentration of the second messenger molecule cAMP through inhibition of adenylate cyclase. In the feces, mainly 11-OH-THC was detected. Information about Stockingtease, The Hunsyellow Pages, Kmart, Msn, Microsoft, Noaa, Diet, Realtor, Motherless.com, Lobby.com, Hot, Kidscorner.com, Pof, Kelly Jeep, Pichuntercom, Gander Mountain, Accuweather, Bank Of America, Hotels, Zillow. Since the law counted only Δ-9 THC, Δ-8 THC was considered legal to sell under the farm bill and was sold online. Although the chemical formula for THC (C21H30O2) describes multiple isomers,[9] the term THC usually refers to the Delta-9-THC isomer with chemical name (−)-trans-Δ⁹-tetrahydrocannabinol. [45] Breath sampling as a noninvasive method is in development to detect THC, which is difficult to quantify in breath samples. [57], "THC" redirects here. Sympaticoca Stockingtease, The Hunsyellow Pages, Kmart, Msn, Microsoft, Noaa, Diet, Realtor, Motherless.com, Lobby.com, Hot, Kidscorner.com, Pof, Kelly Jeep, Pichuntercom, Gander Mountain, Accuweather, Bank Of America, Hotels, Zillow. [46], THC was first isolated and elucidated in 1969 by Raphael Mechoulam and Yechiel Gaoni at the Weizmann Institute of Science in Israel. THC is also limited in its efficacy compared to other cannabinoids due to its partial agonistic activity, as THC appears to result in greater downregulation of cannabinoid receptors than endocannabinoids. La Musica è un qualcosa che ci accompagna durante la nostre vita. One24 Green Tickets, Blogs, News, 2012, Home Business, Network Marketing, Social Networking Sites, Twitter, Apps. Negozio di Musica Digitale su Amazon.it. A 1972 study gave up to 9000 mg/kg of THC to dogs and monkeys without any lethal effects. 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